Types of Cannabinoids

Is THC-O Safe?

Safety in the cannabis industry is a hot topic, that’s not a mystery for anyone. But the real question is, why is it a hot topic?

The answer is simple; the industry is evolving quickly, so quickly that it’s hard for regulations to keep pace. In many cases, this means that product launches happen before regulations are 100% finalized. This includes legal regulations, but also quality and safety standards.

THC-O is one of the trending cannabinoids of the year, so we decided to take a deeper look into how safe it is.

What Is THC-O?

THC-O has been around since the 1940s when U.S. military scientists studied the compound along with other drugs that are today labeled as schedule I substances like LSD and Psilocybin. Back then, the short-term exposure effects of the substance were assessed and it was determined that it was not ‘worth’ pursuing further as the appearance of it in the illegal market was almost null.

It was only 30 years later until THC-O products made their way to the illegal market. The delay should probably be attributed to the technical difficulty of extracting cannabinoids and converting them into THC-O that can be sold. Even then, the pursuit of ‘cracking down’ on illegal THC-O for sale was abandoned.

THC-O Acetate is made by adding acetic anhydride to the THC molecule, even if this one is extracted from hemp, which is the most common process used when producing legal THC-O products.

This way the federal regulation that covers hemp-derived products technically covers THC-O as well. However, its legal status can be quite ambiguous. If you want to learn more about THC-O’s legal standing then visit our blog by clicking here.

That said, the manufacturing process of THC-O can be extremely difficult and even more complex if it is to be done well and safely. By all means, a laboratory environment is required and we only recommend consuming THC-O from reliable sources.

Manufacturing THC-O Acetate involves chemicals, and this means it should involve a step where these chemicals are removed from the final product, a type of process that is not easily done unless there is experience behind it and where safety can only be ensured by running product tests on every batch and publishing them online for the consumer to access, as you’ll find on the Hemmfy Marketplace.

At the moment, regulations surrounding THC-O are uncertain and confusing for lack of a better word, which ultimately makes THC-O safety a question of trusting your source. At Hemmfy we do our best to only provide THC-O products we trust, but we highly recommend doing your own research. We do not intend to encourage THC-O consumption and would prefer it if this was a personal decision. 

The Best THC-O Products (Edibles Only)

That said, we do carry a large selection of THC-O products you can browse through. We’ve also included a list of a few of our top-selling products to point you in the right direction in case you don’t know where to start.

Watermelon Blast Delta 8 - THC-O Gummies by Kush Burst

Watermelon Blast Delta 8 - THC-O Gummies by Kush Burst

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These Kush Burst gummies are made with a mix of hemp-derived Delta-8 and THC-O and a delicious blast of watermelon flavor. Each bag comes with a total of 10 gummies and 500mg of cannabinoids (50mg per gummy).

THC-O Gummies by Sticky Green

THC-O Gummies by Sticky Green

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Sticky Green gummies come in a 15-count resealable jar that keeps your THC-O products safe for a longer time. Each gummy is dosed with exactly 25mg of hemp-derived THC-O and comes in 7 different delicious fruit flavors. Sticky Green gummies are third-party lab tested according to the brand.

Strawberry Glue Indica THC-O Gummies by A Gift From Nature

Strawberry Glue Indica THC-O Gummies by A Gift From Nature

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A Gift From Nature makes these amazing strain-specific THC-O gummies made from Strawberry Glue, an Indica strain whose effects are sure to show when consumed. Each unit contains 15 gummies and a total of 225mg of THC-O; that’s 15mg per gummy.

Is THC-O Safe?

As you might suspect by now, the answer to this question will come down to who you purchase products from. Following strict manufacturing practices that focus on THC-O safety can only be entrusted to brands that have proven they can in fact be trusted.

When it comes to any new substance in any industry, particularly one as young as the legal cannabis industry, it’s always wise to do your research before consuming. So THC-O safety will also be dependent on how well you know your consumption tolerance, personal medical situation, and the purity of the product you purchase. That’s why we always encourage you to take a look at the COAs provided by the brands we carry before making a purchase and only click the ‘buy’ button when completely satisfied.

Some companies have been able to launch products that are not completely clean, which makes it even more important to have COAs that can prove the safety of your THC-O. We can say that we trust the brands we carry, but if you want to be 100% safe, then your best bet is to wait for regulations to evolve and finalize a set of safety standards.

If you are adamant about trying THC-O and would like to try the safest options possible, then we would suggest going with THC-O edibles or THC-O tinctures since they don’t involve any form of inhalation.

How is THC-O Acetate Made?

THC-O Acetate is called that way for a reason; manufacturers make it by adding Acetic Anhydride to the THC molecule. In the modern cannabis industry, THC-O is usually made from cannabinoids extracted from hemp sources. This method puts THC-O in a legal gray area as it is derived from a plant that is federally legal.

THC-O Acetate

Most of the time, according to manufacturer sources, we found that THC-O is made from hemp-derived Delta 8 THC, a compound that is already difficult to find. This would also explain why the process to make THC-O can be so complicated.

Make sure to visit our blog on the subject if you’re interested in knowing more about where THC-O comes from.

Potential THC-O Effects

It usually takes longer for consumers to feel the effects of THC-O than other forms of THC, according to user reports. Especially if consumed in the form of edibles that have to make their way through the digestive system before being absorbed into the bloodstream.

This ‘delay’ is attributed to THC-O being metabolized by the liver, regardless of the product category you purchase (edibles, vapes, etc.). Once the compound is metabolized and consumed by the body, its effects are said to be much stronger than Delta 9 THC.


We need to say that the effects of THC-O are not validated by conclusive clinical research and will highly depend on the user’s tolerance, amount consumed, and a series of other variables. But it’s also our responsibility to warn you as a user that you most likely are in for a very intense experience.

When consuming THC-O edibles, it’s also likely for effects to take even longer, even up to 3 hours or more. This can ultimately end in heavily sedating physical effects, so you should definitely plan ahead for that.

Does THC-O Show Up on a Drug Test?

The truth is that we can’t say for sure. But it will most likely show up. Because THC-O is considered a prodrug, meaning it will leave the body in the form of Delta 9 THC (traditional THC). In that case, it more than likely will be detected by drug tests screening for THC metabolites.

Hemmfy articles and blogs are meant to entertain and educate. However, we are not medical professionals and do not intend to give medical advice through them.

The knowledge around CBD and other cannabis-derived products is growing and constantly changing, as does their legal status. Hence, we recommend checking with your local authorities and a licensed physician prior to consumption.

Simon Cartagena

Simon Cartagena is a full-time cannabis copywriter. This has led him to write for companies like Hemmfy.com where he acts as Senior Content Writer and other world-renowned cannabis publications. Simon has created Content Marketing strategies and articles that have helped company revenues increase by up to 1,000%. Simon’s goal is to help people understand cannabis in an industry where misinformation seems to be predominant.