CBD has exploded into the world, but there’s more to Hemp than just cannabidiol. Have you heard of CBG?
Have you ever heard of Cannabigerol? The Hemp Plant is known to contain over 120+ compounds, yet most of the attention has gone to CBD.
This article covers Cannabigerol, also known as CBG, and answers all of your questions on the interesting cannabinoid.
You’ll learn why it’s so expensive to produce, the benefits of CBG oil, and scientific studies on the benefits of Cannabigerol.
What is CBG?
CBG is short for Cannabigerol and is considered a minor or secondary cannabinoid that’s primarily sourced from the Hemp plant.
First discovered in the 1960s, CBG is the precursor from which all other cannabinoids are synthesized, which is why it’s known as the “stem cell” of cannabinoids.
In short, Cannabigerol acid (CBGA) is first synthesized in Hemp and then used as a building block to create other cannabinoids.
Research into CBG indicates that it has a high safety profile and is non-psychotropic, which means it isn’t associated with any psychoactive effects known to THC.
Differences Between CBD, THC, and CBG
The main difference between THC and other cannabinoids is that THC can cause psychoactive effects, while compounds such as CBD and CBG do not.
CBG appears to be very similar to CBD. However, the two cannabinoid compounds have a different molecular structure. CBD is considered a major cannabinoid due to being the main cannabinoid expressed in Hemp plants.
As mentioned, CBG is the primary building block from which all other cannabinoids are synthesized, in particular the acidic precursor to cannabigerol, CBGa.
Although it’s Hemp’s “stem cell” cannabinoid, by the time Hemp reaches maturity it only contains about 1% or less CBG. As Hemp matures, more CBG is converted into CBD, THC, and other cannabinoids.
Now that cannabigerol’s beneficial properties are getting more attention, many cultivators are developing strains that express CBG in higher concentrations. However, as you’ll learn in the section there’s somewhat of a paradox in cultivating Hemp specifically for CBG oil.
Unfortunately, due to lengthy Hemp prohibition and the fact that CBD and THC have taken center stage, little research into the effects of CBG in humans has been done.
Why CBG is So Expensive to Make
Although there is a large array of Hemp plants with unique genetics and chemical compositions, the vast majority of plants that reach maturity will only contain about 1% of CBG content.
This is a reason why CBG is more expensive than it’s cannabinoid counterpart, Cannabidiol. Hemp growers have two choices if they want to produce CBG oil.
Either Hemp farmers have to sacrifice an entire crop to being harvested early, prior to the conversion of CBG into other cannabinoids, or they let the crop go all the way to maturity. By this point, however, most CBG content has already converted into other cannabinoids.
It takes thousands of pounds of biomass to create small amounts of CBG isolate. Cultivators have bred Hemp varieties that contain up to 20% CBD content. However, that same crop would require twenty times the amount of biomass to produce the same amount of CBG Oil.
Until recently, very few Hemp strains have been cultivated to produce high levels of CBG, despite the increasing consumer demand. This low supply and high demand is also the main reason why CBG commands such a high price tag.
CBG Benefits to Endocannabinoid System
As mentioned previously, large-scale research into the beneficial properties of CBG is still lacking, but we do have some early findings that indicate the compound has properties that activate endocannabinoid receptors.
While a further scientific investigation is required to confirm any of CBG’s benefits to any specific health problems, early findings are promising.
Compounds such as CBG are thought to boost endocannabinoid tone, signaling, and function, which may help balance a wide range of health issues.
There aren’t any clinical studies on CBG in humans, but laboratory research and studies on animals is being conducted to determine the compound’s pharmacological properties and potential health effects.
Scientific Studies on CBG
In vitro experiments using cannabigerol have demonstrated that the cannabinoid compound has properties including -
According to a recent lab study on CBG’s neuroprotectant properties published in the International Journal of Molecular Sciences -
“CBG restored cell anti-oxidant defense, increasing the expression of Nrf-2, reduced oxidative stress and inflammatory markers.”
While in vitro and animal studies don’t always translate to human results, these early findings are promising.
Another study, published in the journal, Neurotherapeutics, explores the effect of CBG in two animal models of Huntington’s disease, a rare neurodegenerative condition that leads to the deterioration of brain cells and dementia.
The researchers found that CBG improved inflammation markers and antioxidant defenses. The study also indicated that CBG-treated animals had a significant reduction in the genetic mutations responsible for Huntington’s disease.
Further studies investigating CBG’s properties in animal models of disease have also produced significant results in regards to bladder health.
A paper published in the journal, Natural Product Communications, found that CBG was more effective at significantly modifying bladder contraction induced by electrical stimulation than other cannabinoids, including CBD.
These preliminary findings suggest a tremendous therapeutic potential of cannabinoids such as CBG, however, further research is necessary to validate and confirm these benefits in humans.
Taking CBG oil
CBG is available in various types of products formulated for a wide range of purposes, but its most popular form is as a tincture or CBG isolate.
Both Full-Spectrum CBD oil and Broad-Spectrum CBD oil contain varying amounts of CBG and other secondary cannabinoids. Check the third-party lab results to determine the amount of CBG in any product you’re interested in trying to know how much it may contain.
Some studies indicate that CBG combined with other naturally occurring hemp compounds may activate what’s known as the entourage effect.
The entourage effect is a synergistic phenomenon in which the beneficial properties of cannabinoids such as CBG and CBD are exponentially amplified, compared to their isolated effect.
You can learn more about the entourage effect and the cannabinoid spectrum in our other articles linked below.
Be sure to check out our amazing selection of CBG and CBD products by clicking here to browse our full catalog.
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